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PRP (PLATELET RICH PLASMA) & ACell Bio Enhancement Therapy

Shapiro Medical Group offers a Bio-Enhancement therapy that consists of injecting a mixture of PRP (Platelet Rich Plasma) & A-Cell Bio Matrix powder into the scalp. This therapy can be used during surgery to improve the growth of follicular unit grafts or as a standalone non-surgical treatment to thicken areas of miniaturized, thinning hair. It can also be used in the donor area after FUE to stimulate the regrowth of donor hair thereby increasing donor supply. The data suggests that PRP works better with ACell than alone.


PRP (Platelet-Rich Plasm)

PRP is a biologically active substance derived from the patient’s own blood that promotes healing and growth. Blood is made up of plasma & three types of blood cells; red blood cells which carry oxygen; white blood cells which help fight infections; and platelets which are responsible for clotting, scab formation & wound healing. PRP is simply blood that has been specially processed to remove most of the red & white blood cells, leaving behind a concentrated, platelet rich plasma solution containing between five to ten times the normal concentration of platelets. So PRP or Platelet “Rich” Plasma) is simply that…plasma that has a very high concentration of platelets.

PRP has been used successfully to promote healing and growth in orthopedic surgery, dental surgery, and dermatologic surgery for many years. Recently, PRP has been introduced into the field of hair transplant surgery with the hope of improving surgical results & stimulating hair growth.

No one knows the exact mechanism of how PRP stimulates hair growth. We do know that platelets play a critical role in the healing response of all tissue by releasing a variety of growth factors. Some of the ways the growth factors are postulated to work are by encouraging new blood vessel formation, amplifying the natural wound healing process, and stimulating stem cell activity. Specifically, with respect to hair growth it has been suggested that PRP may protect the papilla (root) of the hair from cell death and prolong the anagen or (active growth phase) of a hair follicle. Like many of the medical therapies used to treat hair loss it seems to work best by stimulating thin “miniaturized” hairs to become thicker “terminal” hairs.


ACell Extra Cellular Matrix

ACell is an extracellular matrix derived from biological material that contains a network of collagen, proteins, and growth factors. It, like PRP, has been proven to be useful in wound healing in other areas of medicine. It contains growth factors and is known to recruit progenitor stem cells which is widely believed to help with tissue regeneration. For the last 7-10 years it has been used in hair transplants to help increase graft growth, improve donor scar healing, and promote regrowth of transected hairs.

Therapeutic uses of PRP/ ACell Therapy

  1. PRP/ACell as a Stand Alone Therapy for Thinning Hair: This therapy can be useful in patients with thinning hair who for one reason or another are not a good candidate for, or are not ready for surgery. They may simply have early mild thinning that does not justify surgery. It is also appropriate for patients that may not tolerate or want to use other medical treatments like Propecia or Rogaine. If Propecia and/or Rogaine are being used PRP/ACell can be added to improve results further. It has been an especially helpful addition for women who in general have less surgical and medical options available.
  2. PRP/ACell as an Adjunct During Surgical Transplant Procedures: There are a number of ways that PRP/ACell is believed to potentially be beneficial during surgery:
    • PRP/ACell improves healing of both the donor and recipient area. This could mean less redness, less swelling, less shock loss, & less scarring.
    • PRP/ACell improves survival rates for follicular unit grafts in the recipient area. It may improve the survival rate of the newly transplanted grafts as well stimulate growth in any surrounding miniaturized native hairs that are still present in the recipient area. This can lead to a fuller, thicker result.
    • For FUE it may result in some regrowth of transected hairs in the donor area. It has been theorized that PRP/ACell treatments may help stimulate the regrowth of any transected hairs, or residual stem cells, thereby improving the number of hairs one might get with FUE in the future.